Hsien Wu
Personal
Other names:
Job / Known for: Protein denaturation, blood sugar assay
Left traces: Chinese Journal of Physiology
Born
Date: 1893-11-24
Location: CN Fuzhou, Fujian
Died
Date: 1959-08-08 (aged 66)
Resting place: US
Death Cause: Coronary thrombosis
Family
Spouse: Daisy Yen Wu
Children: Ray J. Wu
Parent(s): Liu Ling and Zhang Zhiqin
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Fullname

Hsien Wu

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吴宪

Slogan
To explore the mysteries of nature and life.
About me / Bio:
Hsien Wu was a Chinese biochemist and geneticist who was the first to propose that protein denaturation was a purely conformational change, i.e., corresponded to protein unfolding and not to some chemical alteration of the protein. This crucial idea was popularized later by Linus Pauling and Alfred Mirsky. Wu was born in Fuzhou, Fujian, China. He studied at the Massachusetts Institute of Technology (undergraduate), and then trained at Harvard University (graduate) under Otto Folin, developing the first small-volume (≥ 0.1-mL sample) assay for blood sugar ( Folin-Wu method ). Wu then returned to China to a position at Peking Union Medical College, becoming head of the biochemistry department in 1924. At the end of that year, he married his research assistant Daisy Yen and would continue collaborating with her until his death in 1959. Wu left China in 1947 to reside in the United States; his wife and children joined him in 1949. Wu's son, Ray J. Wu, became the Liberty Hyde Bailey Professor of Molecular Genetics and Biology at Cornell University, and developed the first method for sequencing DNA and studying transgenic plants. He died in 1959 at the age of 65 and was honored as a pioneer, a visionary, and an inspiration to many.
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